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Estrogen-Dependent Signaling Pathways and Cellular Effects Classical Estrogen Receptors In the 1960s, the group of Jensen and coworkers detected an intracellular protein in ovarian tissue able to interact with E2: the estrogen receptor (ER) (Jensen et al., 2010)

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Standard protocols using 1 to 2 mg daily are operating at a tiny fraction of these thresholds